{"id":129,"date":"2015-04-10T10:37:04","date_gmt":"2015-04-10T10:37:04","guid":{"rendered":"http:\/\/mmdsom.org\/?p=129"},"modified":"2015-04-20T10:11:30","modified_gmt":"2015-04-20T10:11:30","slug":"maternal-smoking-and-the-retinoid-pathway-in-the-developing-lung","status":"publish","type":"post","link":"https:\/\/mmdsom.org\/?p=129","title":{"rendered":"Maternal smoking and the retinoid pathway in the developing lung."},"content":{"rendered":"<p>Maternal smoking is a risk factor for pediatric lung disease, including asthma. Animal models suggest that maternal smoking causes defective alveolarization in the offspring. Retinoic acid signaling modulates both lung development and postnatal immune function. Thus, abnormalities in this pathway could mediate maternal smoking effects. We tested whether maternal smoking disrupts retinoic acid pathway expression and functioning in a murine model.<\/p>\n<p><a href=\"http:\/\/mmdsom.org\/wp-content\/uploads\/2015\/04\/pregnance.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-276\" src=\"http:\/\/mmdsom.org\/wp-content\/uploads\/2015\/04\/pregnance-221x300.jpg\" alt=\"pregnance\" width=\"221\" height=\"300\" srcset=\"https:\/\/mmdsom.org\/wp-content\/uploads\/2015\/04\/pregnance-221x300.jpg 221w, https:\/\/mmdsom.org\/wp-content\/uploads\/2015\/04\/pregnance.jpg 482w\" sizes=\"(max-width: 221px) 100vw, 221px\" \/><\/a> <a href=\"http:\/\/mmdsom.org\/wp-content\/uploads\/2015\/04\/Smoke.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-130\" src=\"http:\/\/mmdsom.org\/wp-content\/uploads\/2015\/04\/Smoke.jpg\" alt=\"Smoke\" width=\"362\" height=\"302\" \/><\/a><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Maternal smoking is a risk factor for pediatric lung disease, including asthma. Animal models suggest that maternal smoking causes defective alveolarization in the offspring. Retinoic acid signaling modulates both lung development and postnatal immune function. Thus, abnormalities in this pathway could mediate maternal smoking effects. We tested whether maternal smoking disrupts retinoic acid pathway expression [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":276,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[10],"_links":{"self":[{"href":"https:\/\/mmdsom.org\/index.php?rest_route=\/wp\/v2\/posts\/129"}],"collection":[{"href":"https:\/\/mmdsom.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mmdsom.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mmdsom.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mmdsom.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=129"}],"version-history":[{"count":3,"href":"https:\/\/mmdsom.org\/index.php?rest_route=\/wp\/v2\/posts\/129\/revisions"}],"predecessor-version":[{"id":277,"href":"https:\/\/mmdsom.org\/index.php?rest_route=\/wp\/v2\/posts\/129\/revisions\/277"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mmdsom.org\/index.php?rest_route=\/wp\/v2\/media\/276"}],"wp:attachment":[{"href":"https:\/\/mmdsom.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=129"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mmdsom.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=129"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mmdsom.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=129"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}